TRIP Transgenic Rats ImmunoPhenomic

TRIP platform has been created in 1996 and has ever since developed Knock-Out (KO) or Knock-In (KI) rat research models for all (academic or private labs, French or international companies…)

• Gene or large genomic locus function analysis: Gene(s) KO
• SNP studies: KI to induce mutation of interest
• Cellular or protein tracking: reporter KI in frame with your marker protein
• Protein or reporter gene overexpression: KI of your protein of interest or reporter under the control of ubiquitous promoter
• Spatio-temporal control by conditional models
• Human cells or tissues engraftment: immunodeficient models

• Remy, S. et al. (2010). New lines of GFP transgenic rats relevant for regenerative medicine and gene therapy. Transgenic Research

• RRG KO (rIL2Rg KO / rRag-1 KO) (cryoconserved)Ménoret, S., et al. (2018). Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models. Transplantation, 102(8), 1271‑1278.
• RRGS (RRG KO with human SIRPα) (alive & cryoconserved)Ménoret, S., et al. 2019. « In Vivo Analysis of Human Immune Responses in Immunodeficient Rats ». Transplantation, novembre. 

• Larcher, T., Lafoux, A., Tesson, L., Remy, S., Thepenier, V., François, V., … Huchet, C. (2014). Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy. PloS One, 9(10), e110371.
• Ouisse, Laure-Hélène, Séverine Remy, Aude Lafoux, Thibaut Larcher, Laurent Tesson, Vanessa Chenouard, Carole Guillonneau, et al. 2019. « Immunophenotype of a Rat Model of Duchenne’s Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment ». Frontiers in Immunology 10 (septembre): 2131.
• Caudal, Dorian, Virginie François, Aude Lafoux, Mireille Ledevin, Ignacio Anegon, Caroline Le Guiner, Thibaut Larcher, et Corinne Huchet. 2020. « Characterization of brain dystrophins absence and impact in dystrophin-deficient Dmdmdx rat model ». PLoS ONE 15 (3).